Cross-reactivity with third and second generation cephalosporins in truly penicillin allergic patients
نویسندگان
چکیده
منابع مشابه
Use of cephalosporins in patients with immediate penicillin hypersensitivity: cross-reactivity revisited.
A 10% cross-reactivity rate is commonly cited between penicillins and cephalosporins. However, this figure originated from studies in the 1960s and 1970s which included first-generation cephalosporins with similar side-chains to penicillins. Cephalosporins were frequently contaminated by trace amount of penicillins at that time. The side-chain hypothesis for beta-lactam hypersensitivity is supp...
متن کاملImmediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins.
BACKGROUND Allergy to cephalosporins has mainly been evaluated in the context of patients with confirmed penicillin allergy. The problem of studying cross-reactivity in subjects primarily sensitized to cephalosporins and potentially allergic to penicillins has not been sufficiently addressed. OBJECTIVE To evaluate the in vitro IgE response and cross-reactivity to betalactams in patients with ...
متن کاملPenicillin-allergic patients: Use of cephalosporins, carbapenems, and monobactams
Antigenic components of penicillins — In order to understand the possible cross reactivity among penicillins, cephalosporins, carbapenems and monobactams, it is helpful to review the potential allergens in penicillins. Patients with IgE-mediated allergy to penicillins may be reactive to the beta-lactam ring structure that is common to all penicillins, or to the R-group side chains that distingu...
متن کاملThe use of cephalosporins in penicillin-allergic patients: a literature review.
BACKGROUND The practice of avoiding cephalosporin administration to penicillin-allergic patients persists despite the low rate of cross reactions between both groups of antibiotics. OBJECTIVE The purpose of this literature review is to evaluate the published evidence regarding the commonly held belief that patients with a history of an allergic reaction to penicillin have a significantly incr...
متن کاملEvaluation of immediate allergic reactions to cephalosporins in non-penicillin-allergic patients.
BACKGROUND Cephalosporins can induce severe or life-threatening IgE-mediated reactions in some individuals. In this study, we wish to describe a group of non-penicillin-allergic patients who were evaluated for immediate allergic reactions to cephalosporins. METHODS The patients were assessed by skin tests with the culprit cephalosporin as well as with other cephalosporins and penicillins. If ...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2020
ISSN: 1939-4551
DOI: 10.1016/j.waojou.2020.100245